Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B
Identifieur interne : 000159 ( France/Analysis ); précédent : 000158; suivant : 000160Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B
Auteurs : Neil Vasdev [Canada] ; Oleg Sadovski [Canada] ; Armando Garcia [Canada] ; Frédéric Dollé [France] ; Jeffrey H. Meyer [Canada] ; Sylvain Houle [Canada] ; Alan A. Wilson [Canada]Source :
- Journal of Labelled Compounds and Radiopharmaceuticals [ 0362-4803 ] ; 2011-08.
Abstract
Carbon‐11‐labelled (S)‐5‐methoxymethyl‐3‐[6‐(4,4,4‐trifluorobutoxy)benzo[d]isoxazol‐3‐yl]oxazolidin‐2‐[11C]‐one ([11C]SL25.1188), a promising reversibly binding radiotracer for imaging central monoamine oxidase B, was rapidly prepared via an intramolecular cyclization reaction in an automated one‐pot procedure directly from [11C]CO2, thereby precluding the use of [11C]COCl2. Formulated [11C]SL25.1188 was isolated in 12 ± 1% uncorrected radiochemical yield, based on starting [11C]CO2, with a specific activity of 37 ± 2 GBq/µmol at the end of synthesis (30 min; n = 3). Radiochemical and enantiomeric purities were both >99%. The methodology described herein offers an efficient production of [11C]SL25.1188 at ambient temperature and is suitable for human imaging studies.
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DOI: 10.1002/jlcr.1908
Affiliations:
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Radiopharm</title><idno type="ISSN">0362-4803</idno><idno type="eISSN">1099-1344</idno><imprint><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2011-08">2011-08</date><biblScope unit="volume">54</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="678">678</biblScope><biblScope unit="page" to="680">680</biblScope></imprint><idno type="ISSN">0362-4803</idno></series><idno type="istex">72E33E45E4BB7A9B3D56F08E0CEE2BEF984EC951</idno><idno type="DOI">10.1002/jlcr.1908</idno><idno type="ArticleID">JLCR1908</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0362-4803</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Carbon‐11‐labelled (S)‐5‐methoxymethyl‐3‐[6‐(4,4,4‐trifluorobutoxy)benzo[d]isoxazol‐3‐yl]oxazolidin‐2‐[11C]‐one ([11C]SL25.1188), a promising reversibly binding radiotracer for imaging central monoamine oxidase B, was rapidly prepared via an intramolecular cyclization reaction in an automated one‐pot procedure directly from [11C]CO2, thereby precluding the use of [11C]COCl2. Formulated [11C]SL25.1188 was isolated in 12 ± 1% uncorrected radiochemical yield, based on starting [11C]CO2, with a specific activity of 37 ± 2 GBq/µmol at the end of synthesis (30 min; n = 3). Radiochemical and enantiomeric purities were both >99%. The methodology described herein offers an efficient production of [11C]SL25.1188 at ambient temperature and is suitable for human imaging studies.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Ontario</li></region><settlement><li>Orsay</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Vasdev, Neil" sort="Vasdev, Neil" uniqKey="Vasdev N" first="Neil" last="Vasdev">Neil Vasdev</name></noRegion><name sortKey="Garcia, Armando" sort="Garcia, Armando" uniqKey="Garcia A" first="Armando" last="Garcia">Armando Garcia</name><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H." last="Meyer">Jeffrey H. Meyer</name><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H." last="Meyer">Jeffrey H. Meyer</name><name sortKey="Sadovski, Oleg" sort="Sadovski, Oleg" uniqKey="Sadovski O" first="Oleg" last="Sadovski">Oleg Sadovski</name><name sortKey="Vasdev, Neil" sort="Vasdev, Neil" uniqKey="Vasdev N" first="Neil" last="Vasdev">Neil Vasdev</name><name sortKey="Vasdev, Neil" sort="Vasdev, Neil" uniqKey="Vasdev N" first="Neil" last="Vasdev">Neil Vasdev</name><name sortKey="Vasdev, Neil" sort="Vasdev, Neil" uniqKey="Vasdev N" first="Neil" last="Vasdev">Neil Vasdev</name><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name></country><country name="France"><noRegion><name sortKey="Dolle, Frederic" sort="Dolle, Frederic" uniqKey="Dolle F" first="Frédéric" last="Dollé">Frédéric Dollé</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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